Adrenal fatigue is a term that has been used for a collection of symptoms that they attribute to chronic stress and the overworking of the adrenal glands. The adrenal glands are responsible for producing hormones such as cortisol and adrenaline, which are involved in the body's response to stress. Proponents of the adrenal fatigue concept suggest that chronic stress can lead to an overproduction of these hormones, eventually causing the adrenal glands to become fatigued and unable to produce adequate levels of hormones, leading to various symptoms.