Hormone imbalances can affect both men and women and cause a variety of symptoms. Common symptoms of hormonal imbalance include: In women, irregular periods or changes in the menstrual cycle may indicate a hormonal imbalance. Hot flashes and night sweats: These are common in women during menopause and may indicate a drop in estrogen levels. Difficulty or Weight Gain Weight Loss: Hormonal imbalances, particularly those involving insulin and thyroid hormones. Fatigue: Chronic fatigue or low energy levels may indicate a thyroid hormone imbalance (hypothyroidism). Mood swings, anxiety, and depression can all be caused by hormonal imbalances, particularly those involving estrogen and progesterone. Libido Loss: Changes in sexual desire can occur as a result of sex hormone imbalances.